List of human tumor suppressors

List of gene ids known to be human tumor suppressors. It is used as default tsList argument in applyFilters() if not specified otherwise and the removeCancer argument is set to TRUE. In such a sceneario, truncating mutations in these human tumor suppressor genes are not counted for TMB quantification. This is a corretive strategy usually required for panel-based TMB quantification to avoid upward skewing bias due to panel enrichment in cancer genes.

HumanTumorSuppressors

Format

character vector with 1217 elements

Source

From the TSGene 2.0 database available at https://bioinfo.uth.edu/TSGene/. See Zhao et al. "TSGene 2.0: an updated literature-based knowledgebase for tumor suppressor genes" NAR 2016. PMID: 26590405