Dataset containing tumor mutational burden and clinical data from a published study

Dataset from Hellman et al., Cancer Cell 2018 containing the original WES-based TMB value and clinical response from the study and a simulated panel-based TMB value calculated in silico by subsetting the WES dataset to only contain genes targeted by a custom panel used as example.

Hellman_SimulatedFM1Panel_WES

Format

A data frame with 74 rows and 4 variables

PatientID

Patient identifier

ClinicalResponse

Clinical response to immunotherapy; responder or nonresponder

Panel.NumMuts

Panel-based tumor mutational burden, in total number of mutations

WES.NumMuts

WES-based tumor mutational burden, in total number of mutations

Source

provided as supplementary table by Hellman et al. in "Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination With Ipilimumab in Small-Cell Lung Cancer". Cancer Cell 2018 (PMID: 29731394) and modified to add simulated panel TMB